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Manic episodes last at least seven days at a time, and symptoms can be so intense a person may need hospitalization. Depressive episodes may also occur, lasting at least two weeks. This type has a pattern of depressive and hypomanic episodes without any intense manic episodes. It may be misdiagnosed as depression. It involves alternating episodes of hypomania and depression. It lasts at least two years in adults and one year in children and adolescents

This is an area of the brain essential to working memory, impulse control and the ability to stay focused on tasks

Fifth on the list, behind ADHD, was alcohol abuse, which ages the brain by an average of . years.

Perhaps the most convincing data come from twin studies.

These moods range from periods of extremely up, elated, and energized behavior (known as manic episodes) to very sad, down, or hopeless periods (known as depressive episodes). Less severe manic periods are known as hypomanic episodes.